Palmer's best-known work is the role of Dr. Lauren Lewis, a major character in the Canadian series Lost Girl (2010–2015). Her television work includes made-for-TV movies The Reagans (2003) as Patti Reagan; Out of the Ashes (2003) as Didi Goldstein; and Devil's Perch (2005) as Abby. She had a recurring role in the CTV teen drama/comedy series Instant Star as rock singer Patsy Sewer (2006–2007); and was a co-lead in the Global drama The Guard as Coast Guard rescue specialist Carly Greig (2008–2009) (for which she had to conquer her fear of water). Guest appearances include The CW espionage drama Nikita in the episode "Girl's Best Friend" (2011) as Anya Vimer, a terrorist who tries to sabotage a peace summit; the HBO Canada comedy Call Me Fitz in the episode "Don of the Differently Abled" (2011) as Laura, an unhinged amputee with plans for an escort service for disabled people; the CTV fantasy drama The Listener in the third season finale "The Shooting" (2012) as Staff Sgt. McCoy, an investigator for Internal Affairs. Palmer appeared in the online dating web series comedy Seeking Simone in the episode "1. 1: Single Lesbian Psychos" (2009) as Rebecca. After Lost Girl, she joined the main cast of science-fiction series Dark Matter in the role of The Android (2015–2017) and hosted After Dark, the series' online aftershow for third-season episodes.